TB Comorbidities

This module handles modeling of co-occurring conditions with tuberculosis, including HIV and malnutrition.

Main Comorbidities Module

Available Comorbidity Types

HIV Co-infection (tbsim.comorbidities.hiv)

Modeling of TB-HIV co-infection dynamics and interactions

Malnutrition (tbsim.comorbidities.malnutrition)

Impact of malnutrition on TB progression and treatment outcomes

Connector Classes

Specialized classes that integrate TB with specific comorbidities

Subpackages

• HIV Comorbidity Module
  • HIV Disease Model
    • HIVState
      • HIVState.ATRISK
      • HIVState.ACUTE
      • HIVState.LATENT
      • HIVState.AIDS
    • HIV
      • HIV.__init__()
      • HIV.set_prognoses()
      • HIV.step()
      • HIV.init_results()
      • HIV.update_results()
  • HIV State Enumeration
  • HIV Interventions
  • TB-HIV Connector
    • TB_HIV_Connector
      • TB_HIV_Connector.__init__()
      • TB_HIV_Connector.compute_tb_hiv_risk_rr()
      • TB_HIV_Connector.step()
  • Model Overview
  • Key Features
  • Usage Examples
  • Mathematical Framework
• Malnutrition Comorbidity Module
  • Malnutrition Disease Model
    • Malnutrition
      • Malnutrition.LMS_data
      • Malnutrition.dweight
      • Malnutrition.dweight_loc()
      • Malnutrition.dweight_scale()
      • Malnutrition.weight()
      • Malnutrition.height()
      • Malnutrition.lms()
      • Malnutrition.__init__()
      • Malnutrition.set_initial_states()
      • Malnutrition.step()
      • Malnutrition.init_results()
      • Malnutrition.update_results()
  • TB-Malnutrition Connector
    • TB_Nutrition_Connector
      • TB_Nutrition_Connector.sim
      • TB_Nutrition_Connector.pars
      • TB_Nutrition_Connector.__init__()
      • TB_Nutrition_Connector.supplementation_rr()
      • TB_Nutrition_Connector.lonnroth_bmi_rr()
      • TB_Nutrition_Connector.ones_rr()
      • TB_Nutrition_Connector.compute_relsus()
      • TB_Nutrition_Connector.step()
  • Model Overview
  • Key Features
  • Usage Examples
  • Mathematical Framework
  • Data Requirements

Key Features

• Bidirectional Interactions: Model how comorbidities affect TB and vice versa

• State Transitions: Complex state modeling for multiple conditions

• Treatment Interactions: Account for drug interactions and side effects

• Risk Stratification: Different risk profiles for various comorbidity combinations

• Network Effects: Social network impacts on comorbidity spread

Usage Examples

TB-HIV co-infection modeling:

from tbsim.comorbidities.hiv import HIV
from tbsim import TB

tb = TB()
hiv = HIV()

sim = ss.Sim(diseases=[tb, hiv])
sim.run()

TB with malnutrition:

from tbsim.comorbidities.malnutrition import Malnutrition
from tbsim import TB

malnutrition = Malnutrition()
sim = ss.Sim(diseases=malnutrition)

Connector Classes

TB_HIV_CNN: Connects TB and HIV models for integrated simulation TB_Nutrition_Connector: Links TB and malnutrition models

These connector classes ensure proper interaction between different disease models and maintain consistency in the simulation.

For detailed information about specific comorbidity types, see the individual subpackage documentation above.